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10.1016/j.tiv.2015.07.024 Toxicol
While GLP-1RAs can directly stimulate mTORC1 in some contexts, the net effect of the impaired mTOR signaling during sustained caloric deficit may favor catabolism [34]
Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025
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